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KMID : 0604520100360030233
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Journal of the Society of Cosmetic Scientists of Korea
2010 Volume.36 No. 3 p.233 ~ p.240
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Preparation of Natural Compounds-tripeptides Derivatives and Their Melanogensis Inhibitory Activity
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Shin Kyung-Hoon
Lee Jae-Ho
Ryu Geun-Seok
Jee Kyung-Yup
Park Soo-Nam
Kim Jai-Il
Cho In-Sik
Kim Han-Young
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Abstract
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Derivatives of a novel natural compunds, melanostatin (PLG-) were prepared by solid phase synthesis[1,2] and assayed to evaluate their melanogensis inhibitory activity. Also, a small library (natural compound-XLG-, natural compound-X LG-OH) was prepared with same method for increasing synthetic yield and cost-reduction. PLG- (Proline-Leucine-Glycine-) was well-known tripeptide as its -MSH release-inhibiting activity and tyrosinase inhibitory activity[3-5]. In order to choose best candidate for peptide derivatization, various natural compounds were screened by their tyrosinase inhibitory activity. As a result, caffeic acid and coumaric acid were selected. Most of these derivatives showed better activities than the parent natural compound, melanostatin.
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KEYWORD
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melanostatin, caffeic acid, coumaric acid, melanogenesis
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